RAF Typhoon jets have operated alongside French warplanes in a coordinated attack against an hidden munitions depot in Syrian territory employed by the IS group, as stated by the UK's MoD.
The site, pinpointed through reconnaissance, was assessed as housing weapons and explosive materials, the release indicated, and was located in mountains just north of the ancient city of Palmyra in central Syria.
"Our aircraft employed Paveway IV guided bombs to hit a series of approach shafts leading to the site... initial indications are that the objective was successfully hit," the ministry announced.
There was no evidence of any harm to civilians in the attack late on Saturday and all the aircraft returned safely, the defence officials confirmed.
The Typhoon fighters were assisted by a Voyager aerial refuelling aircraft.
Daesh - alternatively referred to as ISIS - imposed militant control over parts of Iraq and Syria until 2019.
"This strike underscores the UK's leading role, and resolve to operate in unison with our allies, to eliminate any re-emergence of the terrorist group and their dangerous and violent ideologies in the Middle East," UK Defence Secretary the Defence Secretary said.
RAF aircraft have carried out overwatch operations over Syria to "prevent any attempted resurgence" of Islamic State following its military defeat at the climactic battle in Baghuz in the year 2019, the MoD reported.
"I want to thank every member of the UK armed forces who took part in this operation for their expertise and their bravery," he added. "Including them were thousands of UK service members stationed over Christmas and New Year. This mission, to remove dangerous terrorists who endanger our way of life, highlights how British military are ready to step up, all year round, protecting the UK at home and influential overseas."
During December, the American forces executed what it called a "massive strike" targeting Islamic State objectives in the country, following an attack killed two US servicemembers and a local interpreter in the Palmyra area.
The U.N. estimates Daesh still maintains between 5,000 and 7,000 fighters in Iraq and Syria.